This study aimed to determine and identify Sarcocystis spp.infection in sheep of Mashhad city, Iran.From October 2018 to May 2019, the entire esophagus and diaphragm from 100 slaughtered sheep were collected from the Mashhad abattoir.Initially, samples were inspected by the naked eye for the presence of macrocysts.Also, all samples were examined fo
A Bayesian adaptive feasibility design for rare diseases
It is important for researchers to carefully assess the feasibility of a clinical trial prior to 10-inch the launch of the study.One feasibility aspect that needs to be considered includes whether investigators can expect to successfully achieve the sample size needed for their trial.In this manuscript, we present a Bayesian design in which data co
De La Chapelle Syndrome: Clinical and Physical Performance Implications
Gynecomastia in adolescence is a benign condition that mostly disappears spontaneously within approximately two years from onset.When it is associated with hypogonadism, it may suggest a disorder Hair Mask of sexual differentiation.We report the case of a young man (18 years old) with gynecomastia associated with azoospermia, small testes, hyperest
The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies
Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptional signature of